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In vivo molecular imaging of lung cancer in mice
- In vivo molecular imaging of emphysema in mice
- Development of fluorescent bio markers for in vivo assessment of
lung pathology.
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Catheter Based Laser Scanning Confocal Microscopy (CBCM) image of the alveoli in vivo during a breath hold. # |
Laser Scanning Confocal Microscopy system for imaging fresh intact lungs ex vivo at user defined airway pressures, with integrated volume measurement.* |
ex vivo confocal imaging of fresh intact mouse lung through inflation / deflation. Remarkable alveolar heterogeneity. * |
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LSCM image of the alveoli in vivo with nuclei in blue. During a breath-hold. |
3D reconstruction of alveoli from LSCM volume. Extraordinary elastin and collagen fiber network clearly seen. |
LSCM image of the alveoli with nuclear stain. |
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3D reconstruction of alveoli from LSCM volume with pleural confocal slice shown at the bottom. |
LSCM image of the pleural surface ex vivo at high magnification. Mesothelial cells and elastin network clearly visible. |
3D reconstruction of alveoli from LSCM volume. Elastin and collagen fiber network clearly seen. |
* Namati, E., Thiesse, J., de Ryk, J., and McLennan, G., "Alveolar Dynamics During Respiration: Are the Pores of Kohn a Pathway to Recruitment?," Am J Respir Cell Mol Biol, 2007.
# Namati, E., Thiesse, J., de Ryk, J., and McLennan, G., "Dynamic in vivo Alveolar Morphology Using a Novel Laser Scanning Confocal Microscope," presented at 9th Biennial Conference of the Australian Pattern Recognition Society on Digital Image Computing Techniques and Applications (DICTA 2007), Adelaide, Australia, 2007.
©Copyright all rights reserved 2007,2008, Eman Namati.