Whole organ pathology imaging

The Large Image Microscope Array (LIMA) system is comprised of three main components, the large scale custom built vibrating knife microtome, three-axis computer controlled gantry and high resolution microscope with 12 megapixel ccd camera. The system is automated to section large non-embedded lung tissue and acquire high resolution images of the top surface, whilst maintaining alignment between sections. The resultant serial images are compiled into a 3D data set used for registration of histology from sectioned slices to non-invasive imaging modalities such as CT, MRI and PET. One of a kind system, which allows representation of 'ground truth' pathology across 3D imaging modalities. +